(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

Base Information

Chemical Name:(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide
CAS No.:180918-69-8
Molecular Formula:C₁₃H₂₀N₂O₄S
Molecular Weight:300.379
Hs Code.:

Synonyms:(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

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Chemical Property of (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

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Technology Process of (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

There total 4 articles about (S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.1%

: 135124-50-4
N-ethyl-γ-oxo-4-((methanesulfonyl)amino)benzenebutanamide

: 180918-69-8
(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

Guidance literature:: N-ethyl-γ-oxo-4-((methanesulfonyl)amino)benzenebutanamide; With (-)-diisopinocamphenylborane chloride; In tetrahydrofuran; at -25 ℃; for 3.5h;

With 2,2'-iminobis[ethanol]; In tetrahydrofuran; at 20 ℃; for 18h; Further stages.;
DOI:10.1021/jm0004289

Reference yield:

: MeOH-CH₂ Cl₂ on silica gel

: 111-42-2
2,2'-iminobis[ethanol]

: 135124-50-4
N-ethyl-γ-oxo-4-((methanesulfonyl)amino)benzenebutanamide

: 180918-69-8
(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

Guidance literature:: In tetrahydrofuran; methanol; tert-butyl methyl ether; acetonitrile;

Reference yield:

: 100632-57-3
4-((methanesulfonyl)amino)-γ-oxobenzenebutanoic acid

: 180918-69-8
(S)-(-)-N-[4-[4-(ethylamino)-1-hydroxy-4-oxobutyl]phenyl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: Et₃N / tetrahydrofuran / 1.5 h / -12 °C

2.1: Et₃N / tetrahydrofuran / 3 h / -12 °C

3.1: (-)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 3.5 h / -25 °C

3.2: 13.1 percent / diethanoloamine / tetrahydrofuran / 18 h / 20 °C

With triethylamine; (-)-diisopinocamphenylborane chloride; In tetrahydrofuran;
DOI:10.1021/jm0004289