Pyridine, 2-ethyl-3-methoxy- (9CI)

Base Information

• Chemical Name: Pyridine, 2-ethyl-3-methoxy- (9CI)
• CAS No.: 105623-61-8
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.181
• Mol file: 105623-61-8.mol

Synonyms:2-Ethyl-3-methoxypyridine

Chemical Property of Pyridine, 2-ethyl-3-methoxy- (9CI)

Chemical Property:

• Boiling Point: 85 - 90 °C (20 mmHg)
• PSA: 22.12000
• LogP: 1.65260

Purity/Quality:

2-ethyl-3-methoxy-Pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyridine, 2-ethyl-3-methoxy- (9CI)

There total 7 articles about Pyridine, 2-ethyl-3-methoxy- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-3-methoxypyridine (52605-96-6) + ethylmagnesium bromide (925-90-6) → 2-ethyl-3-methoxypyridine (105623-61-8)

Guidance literature:

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; 1.) RT, 2 h, 2.) reflux, 1 h;

DOI:10.3987/COM-89-S75

Reference yield: 77.0%

2-ethyl-3-methoxypyridine 1-oxide (105623-60-7) → 2-ethyl-3-methoxypyridine (105623-61-8)

Guidance literature:

With phosphorus trichloride; In dichloromethane;

Reference yield: 51.0%

2-chloro-3-methoxypyridine (52605-96-6) + triethyl borane (97-94-9) → 2-ethyl-3-methoxypyridine (105623-61-8)

Guidance literature:

With P(PPh₃)4; potassium carbonate; In hexane; N,N-dimethyl-formamide; for 1h; Heating;

DOI:10.3987/COM-89-S75

upstream raw materials:

2-chloro-3-methoxypyridine

triethyl borane

ethylmagnesium bromide

2-ethyl-3-methoxypyridine 1-oxide

Refernces

• 1、 Gilchrist, Thomas L.,Iskander, George M.,Yagoub, Ahmed K.. "Acid-catalysed Rearrangement of 3-Acyl-6-alkoxy-5,6-dihydro-4H-1,2-oxazines: a Route to 3-Alkoxypyridine 1-Oxides". . p. 2769 - 2774. Retrieved 2007/10/02.