52605-96-6

Basic information

• Product Name: 2-Chloro-3-methoxypyridine
• Synonyms: 2-Chloro-3-methoxypyridine ,98%;2-chloro-3-methoxypyridine(SALTDATA: FREE);Pyridine, 2-chloro-3-Methoxy-;2-CHLORO-3-METHOXYPYRIDINE
• CAS NO: 52605-96-6
• Molecular Formula: C₆H₆ClNO
• Molecular Weight: 143.57
• EINECS: 258-039-6
• Product Categories: Pyridine;Heterocycle-Pyridine series
• Mol File: 52605-96-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 90-92°C
• Boiling Point: 210.6 °C at 760 mmHg
• Flash Point: 81.2 °C
• Appearance: crystalline powder
• Density: 1.21 g/cm³
• Vapor Pressure: 0.276mmHg at 25°C
• Refractive Index: 1.517
• Storage Temp.: Room temperature.
• PKA: -0.51±0.10(Predicted)
• Water Solubility: Insoluble in water.
• BRN: 115568
• CAS DataBase Reference: 2-Chloro-3-methoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-3-methoxypyridine(52605-96-6)
• EPA Substance Registry System: 2-Chloro-3-methoxypyridine(52605-96-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39-37
• Hazardous Substances Data: 52605-96-6(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white solid

Uses

It is a pharmaceutical raw material and also used in medicine.

InChI:InChI=1/C6H6ClNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3

Upstream product

• 186581-53-3 diazomethane 
• 6636-78-8 2-chloro-3-hydroxypyridine 
• 20928-63-6 3-methoxy-1H-pyridin-2-one 
• 7295-76-3 3-methoxypyridine 
• 109-00-2 3-HYDROXYPYRIDINE 
• 109-09-1 2-chloropyridine 
• 74-88-4 methyl iodide 

Downstream Products

• 52605-97-7 2,3-dimethoxypyridine 
• 849757-80-8 4-(3-methoxypyridin-2-yl)-benzoic acid 
• 849757-78-4 4-(3-methoxypyridin-2-yl)-3-fluorobenzoic acid 
• 849757-85-3 4-(3-methoxypyridin-2-yl)-3-methoxybenzoic acid 
• 849757-87-5 4-(3-methoxypyridin-2-yl)-3-chlorobenzoic acid 
• 106331-71-9 5,6-dibromo-2,3-dimethoxypyridine 
• 1364917-20-3 2,5,6-trimethoxynicotinic acid 
• 106331-72-0 5-bromo-2,3,6-trimethoxypyridine 
• 1428797-09-4 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylic acid 
• 1428797-08-3 methyl 8-(3-fluorophenyl)-2,3-dimethoxy-5,6-dihydropyrrolo[1,2-h][1,7]naphthyridine-9-carboxylate 
• 53698-49-0 3-methoxy-2-phenylpyridine 
• 1301740-80-6 C₁₇H₁₉FN₄O₂ 
• 1301740-79-3 C₁₇H₁₇FN₄OS 
• 905563-05-5 2‐chloro‐3‐methoxypyridine‐4‐carbaldehyde 

Relevant articles and documents

5 Hetarylmethylene 2,4 diaminopyrimidines

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Synthetic method of 2,5,6-trimethoxy-3-picolinic acid

The invention relates to a synthetic method of 2,5,6-trimethoxy-3-picolinic acid, which mainly solves the technical problem that no effective synthetic methods are provided at present. The synthetic method provided by the invention comprises the following steps: converting 2-chloro-3-hydroxypyridine hydroxy into methoxy; carrying out methoxy nucleophilic substitution of chlorine; carrying out bromination of a pyridine ring; and carrying out methoxy selective substitution of bromine; removing bromine from n-butyllithium, reacting with carbon dioxide, and introducing carboxy so as to obtain 2,5,6-trimethoxy-3-picolinic acid. In the whole synthetic process, intermediates and object products do not need to be separated through a chromatographic column, the raw materials are cheap, and the purification is simple.

SUBSTITUTED 2-AMINOPYRIDINE PROTEIN KINASE INHIBITOR

Disclosed are a 2-aminopyridine derivative having protein kinase inhibition activity, a preparation method and a pharmaceutical composition thereof Also disclosed are uses of the compounds and the pharmaceutical compositions thereof in the preparation of drugs for treating and/or preventing protein kinase-related diseases.