5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine
CAS No.:1282033-20-8
Molecular Formula:C₄₅H₄₃N₅O₈
Molecular Weight:781.865
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

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Chemical Property of 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

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Technology Process of 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

There total 7 articles about 5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1282033-19-5
2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1282033-20-8
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

Guidance literature:: With pyridine; at 20 ℃; for 16h;
DOI:10.1039/c0cc04667a

Reference yield:

: 151390-97-5
2'-O-(1-propyn-3-yl)adenosine

: 1282033-20-8
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

Guidance literature:: Multi-step reaction with 6 steps

1: chloro-trimethyl-silane / pyridine / 0.5 h

2: pyridine / 3 h

3: ammonia / water / 0.33 h / 20 °C

4: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 55 °C / Microwave irradiation

5: palladium 10% on activated carbon / methanol / 0.25 h / 30 °C / 15001.5 Torr

6: pyridine / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; chloro-trimethyl-silane; palladium 10% on activated carbon; ammonia; triethylamine; In pyridine; methanol; water; N,N-dimethyl-formamide; 4: Sonogashira coupling;
DOI:10.1039/c0cc04667a

Reference yield:

: C₁₉H₃₁N₅O₄Si₂

: 1282033-20-8
5'-O-(4,4'-dimethoxytriphenylmethyl)-2'-O-(3-(furan-2-yl)-propyl)-6-N-benzoyladenosine

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 3 h

2: ammonia / water / 0.33 h / 20 °C

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 55 °C / Microwave irradiation

4: palladium 10% on activated carbon / methanol / 0.25 h / 30 °C / 15001.5 Torr

5: pyridine / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; ammonia; triethylamine; In methanol; water; N,N-dimethyl-formamide; 3: Sonogashira coupling;
DOI:10.1039/c0cc04667a