dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate

Base Information

• Chemical Name: dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate
• CAS No.: 1417328-95-0
• Molecular Formula: C₁₂H₁₉O₅P
• Molecular Weight: 274.254
• Mol file: 1417328-95-0.mol

Synonyms:dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate

Chemical Property of dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate

There total 1 articles about dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-methoxyphenyl)propanal (252058-33-6,305820-74-0,5405-83-4) + Dimethyl phosphite (868-85-9) → dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate (1417328-95-0)

Guidance literature:

2-(4-methoxyphenyl)propanal; Dimethyl phosphite; With triethylamine; In dichloromethane; at 0 - 20 ℃; for 10.5h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; water; Inert atmosphere;

DOI:10.1021/ja310980q

Reference yield: 98.0%

dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate (1417328-95-0) → dimethyl (2-(4-methoxyphenyl)propanoyl)phosphonate (1417328-58-5)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ja310980q

Reference yield:

dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate (1417328-95-0) → dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate (1417328-75-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: (p-cymene)ruthenium(II) chloride; C₄₀H₃₂N₂O₃S; Formic acid triethylamine complex / dimethyl sulfoxide / 10 h / 20 - 60 °C / Inert atmosphere

With (p-cymene)ruthenium(II) chloride; C₄₀H₃₂N₂O₃S; Formic acid triethylamine complex; Dess-Martin periodane; In dichloromethane; dimethyl sulfoxide;

DOI:10.1021/ja310980q

upstream raw materials:

2-(4-methoxyphenyl)propanal

Dimethyl phosphite

Downstream raw materials:

dimethyl ((1R,2R)-1-hydroxy-2-(4-methoxyphenyl)propyl)phosphonate

dimethyl (2-(4-methoxyphenyl)propanoyl)phosphonate