C₁₄H₁₁F₃N₂O₂

Base Information

Chemical Name:C₁₄H₁₁F₃N₂O₂
CAS No.:1371608-78-4
Molecular Formula:C₁₄H₁₁F₃N₂O₂
Molecular Weight:296.249
Hs Code.:

C<sub>14</sub>H<sub>11</sub>F<sub>3</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₁₄H₁₁F₃N₂O₂

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Chemical Property of C₁₄H₁₁F₃N₂O₂

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Technology Process of C₁₄H₁₁F₃N₂O₂

There total 8 articles about C₁₄H₁₁F₃N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1371608-77-3
(R)-4-(2-(hydroxymethyl)-5-oxopyrrolidin-1-yl)-3-methyl-2-(trifluoromethyl)benzonitrile

: 1371608-78-4
C₁₄H₁₁F₃N₂O₂

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 112641-23-3
N-(4-Chloro-2-methyl-3-trifluoromethylphenyl)-2,2-dimethyl-propionamide

: 1371608-78-4
C₁₄H₁₁F₃N₂O₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1-methyl-pyrrolidin-2-one / 36 h / 220 °C / Inert atmosphere

2.1: hydrogenchloride; ethanol / 12 h / 80 °C

3.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 0 °C

3.2: 1 h / 0 - 50 °C

4.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 °C

6.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C

With hydrogenchloride; ethanol; hydrogen bromide; caesium carbonate; Dess-Martin periodane; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water;

Reference yield:

: 320-51-4
4-chloro-3-trifluoromethyl-aniline

: 1371608-78-4
C₁₄H₁₁F₃N₂O₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / tetrahydrofuran / 4 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran / 3 h / 0 °C

2.2: 3 h / 0 °C

3.1: 1-methyl-pyrrolidin-2-one / 36 h / 220 °C / Inert atmosphere

4.1: hydrogenchloride; ethanol / 12 h / 80 °C

5.1: sodium nitrite; hydrogen bromide / water / 0.17 h / 0 °C

5.2: 1 h / 0 - 50 °C

6.1: caesium carbonate / 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 12 h / 80 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 4 h / 0 °C

8.1: Dess-Martin periodane / dichloromethane / 3 h / 0 °C

With hydrogenchloride; n-butyllithium; ethanol; hydrogen bromide; caesium carbonate; Dess-Martin periodane; triethylamine; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water;