N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Base Information

Chemical Name:N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone
CAS No.:1345512-75-5
Molecular Formula:C₂₁H₁₆N₄O₃S
Molecular Weight:404.449
Hs Code.:

Synonyms:N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

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Chemical Property of N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

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Technology Process of N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

There total 5 articles about N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 691369-45-6
C₁₄H₁₂N₄O₂S

: 90-02-8
salicylaldehyde

: 1345512-75-5
N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: In butan-1-ol; at 110 ℃; for 12h;
DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

: 4815-36-5
ethyl 2-amino-4-phenyl-thiophene-3-carboxylate

: 1345512-75-5
N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.5 h / 200 °C

2: potassium carbonate / acetone / 48 h / 55 °C

3: hydrazine / ethanol / 12 h / Reflux

4: butan-1-ol / 12 h / 110 °C

With potassium carbonate; hydrazine; In ethanol; acetone; butan-1-ol;
DOI:10.1016/j.bmcl.2011.09.061

Reference yield:

: (4-Oxo-5-phenyl-4H-thieno[2,3-d]pyrimidin-3-yl)-acetic acid ethyl ester

: 1345512-75-5
N'-[(2-hydroxyphenyl)methylene]-(4-oxo-5-phenyl-thieno[2,3-d]pyrimidin-3(4H)-yl)acetohydrazone

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine / ethanol / 12 h / Reflux

2: butan-1-ol / 12 h / 110 °C

With hydrazine; In ethanol; butan-1-ol;
DOI:10.1016/j.bmcl.2011.09.061