N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide
• CAS No.: 73845-01-9
• Molecular Formula: C₁₅H₁₅NO₂S
• Molecular Weight: 273.356
• Mol file: 73845-01-9.mol

Synonyms:N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide

Chemical Property of N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide

There total 4 articles about N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

toluene-4-sulfonamide (70-55-3) + 2-methylphenyl aldehyde (529-20-4) → N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide (73845-01-9)

Guidance literature:

With tris(2,2,2-trifluoroethyl) borate; In tetrahydrofuran; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b00949

Reference yield:

C22H23NO4S2 → N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide (73845-01-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 2h;

DOI:10.1021/jo400956x

Reference yield:

toluene-4-sulfonamide (70-55-3) → N-[(E)-2-methylphenylmethylidene]-4-methylbenzenesulfonamide (73845-01-9)

Guidance literature:

Multi-step reaction with 2 steps

1: formic acid; water / 20 °C

2: sodium hydrogencarbonate / water; dichloromethane / 2 h / 20 °C

With sodium hydrogencarbonate; In formic acid; dichloromethane; water;

DOI:10.1021/jo400956x

upstream raw materials:

toluene-4-sulfonamide

2-methylphenyl aldehyde

Downstream raw materials:

ethyl 2-diazo-3-(N-tosyl)amino-3-(2-methylphenyl)propanoate

ethyl 2-diazo-3-oxo-5-(N-tosyl)amino-5-(2-methylphenyl)pentanoate

C₁₆H₁₇I₂NO₂S