N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

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Chemical Name:N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide
CAS No.:1312572-82-9
Molecular Formula:C₁₆H₁₂F₃N₅OS
Molecular Weight:379.365
Hs Code.:

Synonyms:N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

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Chemical Property of N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

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Technology Process of N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

There total 6 articles about N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 108306-57-6
2-(trimethylsilyl)-5-(trimethylstannyl)-thiazole

: 1312572-81-8
N-(3-bromo-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)acetamide

: 1312572-82-9
N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 15h; Inert atmosphere; microwave;

Reference yield:

: 231287-74-4
N-(3-bromo-5-nitrophenyl)acetamide

: 1312572-82-9
N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonium chloride; iron / ethanol; water / 0.5 h / 80 °C

2: toluene-4-sulfonic acid / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / 90 °C / Inert atmosphere; microwave

With iron; ammonium chloride; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water;

Reference yield:

: 18242-39-2
3,5-dinitrobromobenzene

: 1312572-82-9
N-[3-(1,3-thiazol-5-yl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogen sulfide / toluene; water; methanol / 4 h / 80 °C

2: pyridine / dichloromethane / 1 h / 0 °C

3: ammonium chloride; iron / ethanol; water / 0.5 h / 80 °C

4: toluene-4-sulfonic acid / 1,4-dioxane / 18 h / 100 °C / Inert atmosphere

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 15 h / 90 °C / Inert atmosphere; microwave

With pyridine; sodium hydrogen sulfide; iron; ammonium chloride; toluene-4-sulfonic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene;