(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

Base Information

Chemical Name:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide
CAS No.:712356-40-6
Molecular Formula:C₂₀H₂₈N₂O₂
Molecular Weight:328.455
Hs Code.:

Synonyms:(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

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Chemical Property of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

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Technology Process of (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

There total 6 articles about (1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 712356-40-6
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

Guidance literature:

Reference yield:

: 712356-62-2
C₂₇H₃₄N₂O₂

: 712356-40-6
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; under 2327.23 Torr;
DOI:10.1016/j.bmcl.2007.06.081

Reference yield:

: 1603-79-8
phenylglyoxylic acid ethyl ester

: 712356-40-6
(1α, 5α, 6α)-6-N-(3-azabicyclo [3.1.0] hexyl)-2-cycloheptyl-2-hydroxy-2-phenylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 0 - 20 °C

2: KOH / methanol / 20 °C

3: 1-hydroxybenzotriazole; N-methylmorpholine; N-ethyl-N'-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl / dimethylformamide

4: H₂ / Pd/C / methanol / 3 h / 20 °C / 2327.23 Torr

With 4-methyl-morpholine; potassium hydroxide; hydrogen; benzotriazol-1-ol; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.06.081