2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid

Base Information

• Chemical Name: 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid
• CAS No.: 70203-71-3
• Molecular Formula: C₂₃H₁₈N₂O₃
• Molecular Weight: 370.408
• Mol file: 70203-71-3.mol

Synonyms:2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid

Chemical Property of 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid

There total 4 articles about 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

2-phenyl-4H-3,1-benzoxazin-4-one (1022-46-4) + Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) → 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid (70203-71-3)

Guidance literature:

With acetic acid; for 5h; Reflux;

DOI:10.14233/ajchem.2018.21277

Reference yield:

benzoyl chloride (98-88-4) → 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid (70203-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h / 20 °C

2: acetic acid / 5 h / Reflux

With pyridine; acetic acid;

DOI:10.13005/ojc/340131

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → 2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoic acid (70203-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 0.5 h / 20 °C

2: acetic acid / 5 h / Reflux

With pyridine; acetic acid;

DOI:10.13005/ojc/340131

upstream raw materials:

2-phenyl-4H-3,1-benzoxazin-4-one

Phenylalanine

benzoyl chloride

anthranilic acid

Downstream raw materials:

3-[1-(1H-benzoimidazol-2-yl)-2-phenyl-ethyl]-2-phenyl-3H-quinazolin-4-one

2-Phenyl-3-[2-phenyl-1-(1-piperidin-1-ylmethyl-1H-benzoimidazol-2-yl)-ethyl]-3H-quinazolin-4-one

3-{1-[1-(4-Methyl-piperidin-1-ylmethyl)-1H-benzoimidazol-2-yl]-2-phenyl-ethyl}-2-phenyl-3H-quinazolin-4-one

2-[4-oxo-2-phenylquinazolin-3(4H)-yl]-3-phenylpropanoyl chloride