N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester

Base Information

• Chemical Name: N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester
• CAS No.: 1185198-29-1
• Molecular Formula: C₂₈H₃₆ClN₉O₄
• Molecular Weight: 598.105

Synonyms:N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester

Chemical Property of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester

Chemical Property:

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Technology Process of N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester

There total 2 articles about N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L?arginine benzyl ester mono?p?toluenesulfonate (100295-57-6) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester (1185198-29-1)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L?arginine benzyl ester mono?p?toluenesulfonate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.333333h; pH=9;

In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmc.2009.07.035

Reference yield:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L-Arg-OBzl (57177-89-6) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester (1185198-29-1)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L-Arg-OBzl; In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmcl.2009.05.077

Reference yield: 91.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester (1185198-29-1) → N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-arginine benzyl ester (1185198-49-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃;

DOI:10.1016/j.bmc.2009.07.035

upstream raw materials:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine

L-Arg-OBzl

L?arginine benzyl ester mono?p?toluenesulfonate

Downstream raw materials:

N-(2-chloro-9H-purin-6-yl)-N-cyclopropylglycyl-L-arginine benzyl ester

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