L?arginine benzyl ester mono?p?toluenesulfonate

Base Information

• Chemical Name: L?arginine benzyl ester mono?p?toluenesulfonate
• CAS No.: 100295-57-6
• Molecular Formula: C₇H₈O₃S*C₁₃H₂₀N₄O₂
• Molecular Weight: 436.532
• Mol file: 100295-57-6.mol

Synonyms:L?arginine benzyl ester mono?p?toluenesulfonate

Chemical Property of L?arginine benzyl ester mono?p?toluenesulfonate

Chemical Property:

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Technology Process of L?arginine benzyl ester mono?p?toluenesulfonate

There total 1 articles about L?arginine benzyl ester mono?p?toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

L-arginine (74-79-3,25212-18-4) + toluene-4-sulfonic acid (104-15-4) + benzyl alcohol (100-51-6,185532-71-2) → L?arginine benzyl ester mono?p?toluenesulfonate (100295-57-6)

Guidance literature:

In 2-methyltetrahydrofuran; for 24h; Reflux; Dean-Stark;

DOI:10.1007/s00726-018-2599-2

Reference yield: 30.0%

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine (1185198-27-9) + L?arginine benzyl ester mono?p?toluenesulfonate (100295-57-6) → N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester (1185198-29-1)

Guidance literature:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycine; With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃;

L?arginine benzyl ester mono?p?toluenesulfonate; With 4-methyl-morpholine; In tetrahydrofuran; at 20 ℃; for 0.333333h; pH=9;

In tetrahydrofuran; at 0 - 20 ℃; for 50h;

DOI:10.1016/j.bmc.2009.07.035

upstream raw materials:

L-arginine

toluene-4-sulfonic acid

benzyl alcohol

Downstream raw materials:

N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-arginine benzyl ester