4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

Base Information

Chemical Name:4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid
CAS No.:1229515-34-7
Molecular Formula:C₁₉H₁₈FNO₃
Molecular Weight:327.355
Hs Code.:

Synonyms:4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

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Chemical Property of 4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

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Technology Process of 4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

There total 1 articles about 4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 108-30-5
succinic acid anhydride

: 1086194-87-7
7-fluoro-1-phenyl-1,2,3,4-tetrahydroisoquinoline

: 1229515-34-7
4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

Guidance literature:: With triethylamine; In acetonitrile; at 23 ℃; for 16h;

Reference yield: 81.0%

: 2740-83-2
3-(TRIFLUOROMETHYL)BENZYLAMINE

: 1229515-34-7
4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxobutyric acid

: 1229513-95-4
4-(7-fluoro-1-phenyl-3,4-dihydro-1H-isoquinolin-2-yl)-4-oxo-N-(3-(trifluoromethyl)benzyl)butyric acid amide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 23 ℃;