N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

Base Information

• Chemical Name: N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide
• CAS No.: 911416-37-0
• Molecular Formula: C₂₄H₃₂N₂O₄
• Molecular Weight: 412.529

Synonyms:N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

Chemical Property of N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

Chemical Property:

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Technology Process of N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide

There total 1 articles about N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

N-[6-(4-benzyloxy-butoxy)-3-formyl-pyridin-2-yl]-2,2-dimethyl-propionamide (846036-36-0) + (methoxymethyl)triphenylphosphonium chloride (4009-98-7) → N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (911416-37-0)

Guidance literature:

(methoxymethyl)triphenylphosphonium chloride; With potassium tert-butylate; In tetrahydrofuran; at 0 - 5 ℃; for 0.5h; Inert atmosphere; Large scale reaction;

N-[6-(4-benzyloxy-butoxy)-3-formyl-pyridin-2-yl]-2,2-dimethyl-propionamide; In tetrahydrofuran; at 0 - 5 ℃; Inert atmosphere; Large scale reaction;

DOI:10.1021/op800307k

Reference yield:

N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (911416-37-0) → (Z)-6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-ylamine + (E)-6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-ylamine (1144040-48-1)

Guidance literature:

With sodium hydroxide; ethanol; water; In toluene; at 55 ℃; for 1h;

Reference yield:

N-[6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-yl]-2,2-dimethyl-propionamide (911416-37-0) → 6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-ylamine (911416-38-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; toluene; for 1h; Reflux; Large scale reaction;

DOI:10.1021/op800307k

upstream raw materials:

N-[6-(4-benzyloxy-butoxy)-3-formyl-pyridin-2-yl]-2,2-dimethyl-propionamide

(methoxymethyl)triphenylphosphonium chloride

Downstream raw materials:

(E)-6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-ylamine

6-(4-benzyloxy-butoxy)-3-(2-methoxy-vinyl)-pyridin-2-ylamine

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