Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

Base Information

Chemical Name:Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate
CAS No.:298704-12-8
Molecular Formula:C₃₅H₃₈NO₇PSi
Molecular Weight:643.748
Hs Code.:

Synonyms:Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

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Chemical Property of Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

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Technology Process of Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

There total 5 articles about Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 136918-14-4,85-41-6
phthalimide

: 298704-10-6
Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate

: 298704-12-8
Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;
DOI:10.1039/b002101f

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 298704-12-8
Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 89 percent / toluene 4-sulfonic acid / toluene / 2.5 h / Heating

3: 68 percent / titanium(IV) chloride / CH₂Cl₂ / 0.5 h / -78 °C

4: 70 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

With titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 1: Substitution / 2: Addition / 3: Substitution / 4: Substitution;
DOI:10.1039/b002101f

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 298704-12-8
Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 89 percent / toluene 4-sulfonic acid / toluene / 2.5 h / Heating

3: 68 percent / titanium(IV) chloride / CH₂Cl₂ / 0.5 h / -78 °C

4: 70 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1.5 h / 0 - 20 °C

With titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; 1: Substitution / 2: Addition / 3: Substitution / 4: Substitution;
DOI:10.1039/b002101f