Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate

Base Information

• Chemical Name: Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate
• CAS No.: 298704-10-6
• Molecular Formula: C₂₇H₃₅O₆PSi
• Molecular Weight: 514.631
• Mol file: 298704-10-6.mol

Synonyms:Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate

Chemical Property of Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate

There total 4 articles about Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-(tert-Butyldiphenylsilyloxy)benzaldehyde ethylene acetal (298704-09-3) + phosphorous acid trimethyl ester (121-45-9) → Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate (298704-10-6)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1039/b002101f

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate (298704-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 89 percent / toluene 4-sulfonic acid / toluene / 2.5 h / Heating

3: 68 percent / titanium(IV) chloride / CH₂Cl₂ / 0.5 h / -78 °C

With titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene; 1: Substitution / 2: Addition / 3: Substitution;

DOI:10.1039/b002101f

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-hydroxyethoxy)methylphosphonate (298704-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 24 h / 20 °C

2: 89 percent / toluene 4-sulfonic acid / toluene / 2.5 h / Heating

3: 68 percent / titanium(IV) chloride / CH₂Cl₂ / 0.5 h / -78 °C

With titanium tetrachloride; toluene-4-sulfonic acid; triethylamine; In dichloromethane; toluene; 1: Substitution / 2: Addition / 3: Substitution;

DOI:10.1039/b002101f

upstream raw materials:

3-(tert-Butyldiphenylsilyloxy)benzaldehyde ethylene acetal

phosphorous acid trimethyl ester

meta-hydroxybenzaldehyde

tert-butylchlorodiphenylsilane

Downstream raw materials:

Dimethyl 1-(3-tert-butyldiphenylsilyloxyphenyl)-1-(2-phthalimidoethoxy)methylphosphonate