(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

Base Information

Chemical Name:(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one
CAS No.:263337-30-0
Molecular Formula:C₂₇H₂₇N₃O
Molecular Weight:409.531
Hs Code.:

Synonyms:(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

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Chemical Property of (Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

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Technology Process of (Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

There total 12 articles about (Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-1-acetyl-3-(ethoxy-phenyl-methylene)-indolin-2-one

: 29608-05-7
1-(4-aminobenzyl)piperidine

: 263337-30-0
(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: (E)-1-acetyl-3-(ethoxy-phenyl-methylene)-indolin-2-one; 1-(4-aminobenzyl)piperidine; In N,N-dimethyl-formamide; at 100 ℃; for 0.5h;

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jm900431g

Reference yield:

: C₂₉H₂₉N₃O₂

: 263337-30-0
(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: With sodium hydroxide; In methanol; at 25 ℃; for 5h;
DOI:10.1039/c4md00045e

Reference yield:

: 110-89-4
piperidine

: 263337-30-0
(Z)-3-{phenyl[(4-(piperidin-1-ylmethyl)phenyl)amino]-methylidene}-1,3-dihydro-2H-indolin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran

2: triethylamine / dichloromethane / 16 h / 5 - 20 °C

3: pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane / pyridine / 0.67 h / 70 - 110 °C

4: hydrogenchloride / water; methanol / pH 2 - 3

5: N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; pyridin-1-ium-1-yl[pyridin-1-ium-1-yl(sulfido)phosphinothioyl]sulfanyl-sulfido-thioxo-phosphane; triethylamine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; 5: |Eschenmoser Sulfide Contraction;
DOI:10.1021/acs.joc.1c01269