29608-05-7

Basic information

• Product Name: 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE
• Synonyms: TIMTEC-BB SBB007056;4-(PIPERIDIN-1-YLMETHYL)ANILINE;4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE;4-(1-PIPERIDINYLMETHYL)ANILINE;AKOS MSC-0180;AKOS B014375;ART-CHEM-BB B016020;ART-CHEM-BB B014375
• CAS NO: 29608-05-7
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• EINECS: 1312995-182-4
• Product Categories: Amines and Anilines;Piperidine;Heterocyclic Compounds
• Mol File: 29608-05-7.mol
• Article Data: 24

Chemical Properties

• Melting Point: 90-93
• Boiling Point: 308.694 °C at 760 mmHg
• Flash Point: 126.388 °C
• Appearance: /
• Density: 1.068 g/cm³
• Vapor Pressure: 0.000794mmHg at 25°C
• Refractive Index: 1.555
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 9?+-.0.10(Predicted)
• Water Solubility: immiscible
• CAS DataBase Reference: 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE(29608-05-7)
• EPA Substance Registry System: 4-PIPERIDIN-1-YLMETHYL-PHENYLAMINE(29608-05-7)

Safety Data

• Hazard Codes: C
• Statements: R36/37/38:
• Safety Statements: S26:; S36:
• Hazardous Substances Data: 29608-05-7(Hazardous Substances Data)

Usage

General Description

4-Piperidin-1-ylmethyl-phenylamine is a chemical compound that belongs to the class of organic compounds known as phenylpiperidines. This classification refers to compounds containing a phenylpiperidine skeleton, which consists of a piperidine bound to a phenyl group. As a chemical, it may have various scientific and industrial applications. However, its specific properties such as reactivity, toxicity, and environmental impact would depend on its molecular structure and associated functional groups. It's relevant to note that this chemical does not appear to be widely researched or used, therefore, detailed information about it is limited. As with any chemical substances, proper safety measures should be taken when handling it.

InChI:InChI=1/C12H18N2/c1-2-4-11(5-3-1)10-14-12-6-8-13-9-7-12/h1-5,12-14H,6-10H2

Upstream product

• 59507-44-7 1-(4-nitrobenzyl)piperidine 
• 110-89-4 piperidine 
• 555-16-8 4-nitrobenzaldehdye 
• 100-14-1 4-nitrobenzyl chloride 
• 100-11-8 1-bromomethyl-4-nitro-benzene 

Downstream Products

• 108176-89-2 2-[(4-Piperidin-1-ylmethyl-phenylamino)-methyl]-isoindole-1,3-dione 
• 108176-83-6 3-<4-(N-piperidinomethyl)phenylaminomethyl>benzoxazolin-2-one 
• 108176-92-7 1,3-bis<4-(N-piperidinomethyl)phenylaminomethyl>benzimidazoline-2-thione 
• 108176-86-9 6-chloro-3-<4-(N-piperidinomethyl)phenylaminomethyl>benzoxazolin-2-one 
• 229003-39-8 7-phenyl-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide 
• 229003-49-0 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide 
• 229005-30-5 N-[4-(1-piperidinylmethyl)phenyl]-6-(4-methylphenyl)-2H-1-benzopyran-3-carboxamide 
• 229004-30-2 7-(4-methylphenyl)-N-(4-(piperidinomethyl)phenyl)-2,3-dihydro-1-benzoxepine-4-carboxamide 
• 229004-26-6 2-[(4-methyl)phenyl]-N-{4-[(piperidin-1-yl)methyl]phenyl}-6,7-dihydro-5H-benzo[7]annulene-8-carboxamide 
• 263339-14-6 (Z)-6-nitro-3-[phenyl-(4-piperidin-1-ylmethyl-phenylamino)methylene]-indolin-2-one 
• 689299-71-6 (E)-3-(4'-chloro-biphenyl-4-yl)-N-(4-piperidin-1-ylmethyl-phenyl)-acrylamide 
• 503183-23-1 4-[(4-(piperidin-1-ylmethyl)-phenyl)hydrazono]-4H-pyrazole-3,5-diamine 
• 422518-00-1 (Z)-1-acetyl-5-nitro-3-(phenyl(4-(piperidin-1-ylmethyl)phenylamino)methylene)-indolin-2-one 
• 307302-06-3 N-[4-(piperidinomethyl)phenyl]-7-phenyl-1,2,3,4-tetrahydronaphthalene-2-carboxamide 

Relevant articles and documents

Synthesis of the Kinase Inhibitors Nintedanib, Hesperadin, and Their Analogues Using the Eschenmoser Coupling Reaction

A novel synthetic approach involving an Eschenmoser coupling reaction of substituted 3-bromooxindoles (H, 6-Cl, 6-COOMe, 5-NO2) with two substituted thiobenzanilides in dimethylformamide or acetonitrile was used for the synthesis of eight kinase inhibitor

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Discovery of Selective Inhibitors Targeting Acetylcholinesterase 1 from Disease-Transmitting Mosquitoes

Vector control of disease-transmitting mosquitoes is increasingly important due to the re-emergence and spread of infections such as malaria and dengue. We have conducted a high throughput screen (HTS) of 17,500 compounds for inhibition of the essential AChE1 enzymes from the mosquitoes Anopheles gambiae and Aedes aegypti. In a differential HTS analysis including the human AChE, several structurally diverse, potent, and selective noncovalent AChE1 inhibitors were discovered. For example, a phenoxyacetamide-based inhibitor was identified with a 100-fold selectivity for the mosquito over the human enzyme. The compound also inhibited a resistance conferring mutant of AChE1. Structure-selectivity relationships could be proposed based on the enzymes' 3D structures; the hits' selectivity profiles appear to be linked to differences in two loops that affect the structure of the entire active site. Noncovalent inhibitors of AChE1, such as the ones presented here, provide valuable starting points toward insecticides and are complementary to existing and new covalent inhibitors.