Technology Process of (R)-tert-butyl 2-(3-oxocyclohex-1-enyl)pent-4-ynoate
There total 3 articles about (R)-tert-butyl 2-(3-oxocyclohex-1-enyl)pent-4-ynoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
cyclohexenone;
With
C27H24BNO; bis(trifluoromethanesulfonyl)amide;
In
dichloromethane;
at -20 ℃;
for 0.166667h;
Inert atmosphere;
C9H12N2O2;
In
dichloromethane;
at -20 ℃;
for 1h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1021/ja402873b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 °C
2.1: C27H24BNO; bis(trifluoromethanesulfonyl)amide / dichloromethane / 0.17 h / -20 °C / Inert atmosphere
2.2: 1 h / -20 °C / Inert atmosphere
With
4-acetamidobenzenesulfonyl azide; C27H24BNO; bis(trifluoromethanesulfonyl)amide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
dichloromethane; acetonitrile;
DOI:10.1021/ja402873b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.17 h / 0 °C
1.2: 3-haloprop-1-yne / Reflux
2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 24 h / 0 °C
3.1: C27H24BNO; bis(trifluoromethanesulfonyl)amide / dichloromethane / 0.17 h / -20 °C / Inert atmosphere
3.2: 1 h / -20 °C / Inert atmosphere
With
4-acetamidobenzenesulfonyl azide; C27H24BNO; sodium hydride; bis(trifluoromethanesulfonyl)amide; 1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran; dichloromethane; acetonitrile; mineral oil;
DOI:10.1021/ja402873b
