1-Benzylprolyl chloride

Base Information

Chemical Name:1-Benzylprolyl chloride
CAS No.:105099-19-2
Molecular Formula:C12H14 Cl N O
Molecular Weight:223.702
Hs Code.:
DSSTox Substance ID:DTXSID90516504
Mol file:105099-19-2.mol

Synonyms:1-Benzylprolyl chloride;105099-19-2;1-BENZYLPYRROLIDINE-2-CARBONYL CHLORIDE;SCHEMBL3399606;DTXSID90516504

Suppliers and Price of 1-Benzylprolyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Labseeker
(R)-1-benzyl-pyrrolidine-2-carbonylchloride 95
5g
$ 1833.00

Total 3 raw suppliers

Chemical Property of 1-Benzylprolyl chloride

Chemical Property:

PSA：20.31000
LogP:2.35430
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:223.0763918
Heavy Atom Count:15
Complexity:226

Purity/Quality:

98% ^*data from raw suppliers

(R)-1-benzyl-pyrrolidine-2-carbonylchloride 95 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(N(C1)CC2=CC=CC=C2)C(=O)Cl

Technology Process of 1-Benzylprolyl chloride

There total 4 articles about 1-Benzylprolyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31795-93-4
N-benzyl-L-proline

: 105099-19-2,702629-88-7
N-benzyl-(S)-proline chloroanhydride

Guidance literature:: With thionyl chloride; for 3h; Ambient temperature;
DOI:10.1021/ja00345a057

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 105099-19-2,702629-88-7
N-benzyl-(S)-proline chloroanhydride

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / KOH / propan-2-ol / 6 h / 40 °C

2: SOCl₂ / CH₂Cl₂ / -10 °C

With potassium hydroxide; thionyl chloride; In dichloromethane; isopropyl alcohol;
DOI:10.1016/S0957-4166(98)00449-2

Reference yield:

: 100-44-7
benzyl chloride

: 105099-19-2,702629-88-7
N-benzyl-(S)-proline chloroanhydride

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / 2N NaOH, tetrabutylammonium hydroxide, KI / H₂O / 3 h / 65 °C

2: SOCl₂ / 3 h / Ambient temperature

With sodium hydroxide; thionyl chloride; tetra(n-butyl)ammonium hydroxide; potassium iodide; In water;
DOI:10.1021/ja00345a057