{4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester

Base Information

• Chemical Name: {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester
• CAS No.: 224957-17-9
• Molecular Formula: C₂₅H₂₁F₃N₄O₄S
• Molecular Weight: 530.527

Synonyms:{4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester

Chemical Property of {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester

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Technology Process of {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester

There total 2 articles about {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3-methyl-7-oxo-4-phenyl-7H-isoxazolo[3,4-d]pyridazin-6-yl)-acetic acid ethyl ester (224957-10-2) → {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester (224957-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 38 percent / HNO₃, cerium ammonium nitrate / acetic acid / 50 °C

2: 70 percent / ethanol / 0.33 h / Ambient temperature

With ammonium cerium(IV) nitrate; nitric acid; In ethanol; acetic acid;

DOI:10.1021/jm981107o

Reference yield:

3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one (17334-68-8) → {4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester (224957-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: K₂CO₃ / acetone / Heating

2: 38 percent / HNO₃, cerium ammonium nitrate / acetic acid / 50 °C

3: 70 percent / ethanol / 0.33 h / Ambient temperature

With ammonium cerium(IV) nitrate; nitric acid; potassium carbonate; In ethanol; acetic acid; acetone;

DOI:10.1021/jm981107o

Reference yield: 53.0%

{4-acetyl-6-oxo-3-phenyl-5-[(5-trifluoromethyl-benzothiazol-2-ylmethyl)-amino]-6H-pyridazin-1-yl}-acetic acid ethyl ester (224957-17-9) → [3-methyl-7-oxo-4-phenyl-2-(5-trifluoromethyl-benzothiazol-2-yl)-1,7-dihydro-pyrrolo[2,3-d]pyridazin-6-yl]-acetic acid

Guidance literature:

With sodium hydroxide; In ethanol; Ambient temperature;

DOI:10.1021/jm981107o

upstream raw materials:

(3-methyl-7-oxo-4-phenyl-7H-isoxazolo[3,4-d]pyridazin-6-yl)-acetic acid ethyl ester

3-methyl-4-phenylisoxazolo[3,4-d]pyridazin-7(6H)-one

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