N-methyl phenylalanine methyl ester

Base Information

• Chemical Name: N-methyl phenylalanine methyl ester
• CAS No.: 2439-60-3
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 2439-60-3.mol

Synonyms:N-methyl phenylalanine methyl ester

Chemical Property of N-methyl phenylalanine methyl ester

Chemical Property:

Purity/Quality:

99.00% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl phenylalanine methyl ester

There total 37 articles about N-methyl phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl (S)-2-(benzyloxycarbonyl-methyl-amino)-3-phenylpropionate (24164-73-6) → N-methyl-L-phenylalanine methyl ester (2439-60-3,27442-39-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 30 ℃; for 2h; under 760.051 Torr;

DOI:10.1002/ejic.200700474

Reference yield: 92.0%

(S)-2-(2-Aza-bicyclo[2.2.1]hept-5-en-2-yl)-3-phenyl-propionic acid methyl ester (211567-40-7) → N-methyl-L-phenylalanine methyl ester (2439-60-3,27442-39-3) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In chloroform; for 20h; Ambient temperature;

DOI:10.1021/jo00235a021

Reference yield: 92.0%

N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester (283611-40-5) → N-methyl-L-phenylalanine methyl ester (2439-60-3,27442-39-3)

Guidance literature:

With (2E)-3-(4-hydroxyphenyl-3-methoxyphenyl)-1-phenylprop-2-en-1-one; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1002/(sici)1099-0690(200004)2000:8<1443::aid-ejoc1443>3.0.co;2-5

upstream raw materials:

2-(Benzyloxycarbonyl-methyl-amino)-3-phenyl-propionic acid methyl ester

chloromethyltriethoxysilane

DL-phenylalanine methyl ester

methyl 2-tert-butoxycarbonylamino-3-phenylpropanoate

Downstream raw materials:

N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-N-methyl-L-phenylalanine methyl ester

N-(2-azidobenzoyl)-N-methyl-L-phenylalanine methyl ester

3-phenylpropanoic acid methyl ester

(S)-N-(2-chloroethyl)-N-methylphenylalanine methyl ester

Refernces

• 1、 Kervefors, Gabriella,Kersting, Leonard,Olofsson, Berit. "Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts". supporting information. p. 5790 - 5795. Retrieved 2021/03/08.
• 2、 Liao, Hsuan-Jen,Li, Jikun,Huang, Jhih-Liang,Davidson, Madison,Kurnikov, Igor,Lin, Te-Sheng,Lee, Justin L.,Kurnikova, Maria,Guo, Yisong,Chan, Nei-Li,Chang, Wei-Chen. "Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation". supporting information. p. 1831 - 1835. Retrieved 2018/01/27.