283611-40-5

Basic information

• Product Name: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester
• Synonyms: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester
• CAS NO: 283611-40-5
• Molecular Weight: 378.406
• Mol File: 283611-40-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester(283611-40-5)
• EPA Substance Registry System: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine methyl ester(283611-40-5)

Safety Data

• Hazardous Substances Data: 283611-40-5(Hazardous Substances Data)

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 53793-18-3 (S)-2-(2-nitrophenylsulfonamido)-3-phenylpropanoic acid 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 203873-67-0 (S)-methyl 2-(2-nitrophenylsulfonamido)-3-phenylpropanoate 

Downstream Products

• 2439-60-3 N-methyl-L-phenylalanine methyl ester 
• 856865-82-2 N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylalanine 
• 42267-32-3 2-nitro-benzenethiosulfonic acid S-phenyl ester 

Relevant articles and documents

Synthesis of N-methyl L-phenylalanine for total synthesis of pepticinnamin e

The target compounds 3, 10 and 11 were synthesized through different N-methylation strategies. The concise and efficient preparation of them in large scale was developed and 3, 10 and 11 were obtained in suitable form used for both nitrogen-end and oxygen-end extension in next coupling reaction in peptides synthesis, specifically in total synthesis of natural pepticinnamin E.

Convenient synthesis of N-methylamino acids compatible with Fmoc solid-phase peptide synthesis

Nα-Methylamino acid containing peptides exhibit interesting therapeutic profiles and are increasingly recognized as potentially useful therapeutics. Unfortunately, their synthesis is hampered by the high price and unavaibility of many Nα/