(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Base Information

Chemical Name:(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester
CAS No.:137587-01-0
Molecular Formula:C₂₉H₃₅FNO₅P
Molecular Weight:527.573
Hs Code.:

Synonyms:(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Suppliers and Price of (S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

There total 19 articles about (S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137593-79-4
(S)-4-({(E)-2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

: 137587-01-0
(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; for 72h; under 2585.7 Torr;
DOI:10.1021/jm00113a019

Reference yield:

: 63082-45-1
4-fluoro-2-methylbenzaldehyde

: 137587-01-0
(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

9: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

10: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

11: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium acetate; tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium ethanolate; acetic acid; dimethyl sulfoxide; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 88759-56-2
(S)-bromo-3-hydroxybutyric acid methyl ester

: 137587-01-0
(S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

3: 75 percent / 16.5 h / 155 °C

4: bis(trimethylsilyl)trifluoroacetamide (BSTFA), trimethylsilyl bromide (TMSBr) / CH₂Cl₂ / 20 h / Ambient temperature

5: dicyclohexylcarbodiimide (DCC), pyridine / 20 h / Ambient temperature

6: 1.) TMSDEA, 2.) oxalyl chloride, DMF / 1.) CH₂Cl₂, RT, 1 h, 2.) CH₂Cl₂, 0 deg C - 20 deg C, 1 h

7: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 25 min, 2.) THF, pentane, from -100 deg C to -78 deg C, 30 min

8: tetra-n-butylammonium fluoride, HOAc / tetrahydrofuran / 19 h / Ambient temperature

9: H₂ / 10percent Pd/C / methanol / 72 h / 2585.7 Torr

With pyridine; 1H-imidazole; dmap; bis(trimethylsilyl)trifluoroacetamide; oxalyl dichloride; trimethylsilyl bromide; tetrabutyl ammonium fluoride; hydrogen; tert.-butyl lithium; acetic acid; N,N-dimethyl-formamide; dicyclohexyl-carbodiimide; N,N-diethyl-1,1,1-trimethylsilanamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jm00113a019