63082-45-1

Basic information

• Product Name: 4-Fluoro-2-methylbenzaldehyde
• Synonyms: 4-FLUORO-2-METHYLBENZALDEHYDE;Benzaldehyde, 4-fluoro-2-methyl- (9CI);2-methyl-4-fluorobenzaldehyde;4-Fluoro-o-tolualdehyde;5-Fluoro-2-formyltoluene;5-Fluoro-2-formyltoluene, 4-Fluoro-o-tolualdehyde;Benzaldehyde, 4-fluoro-2-methyl-;4-Fluoro-2-methylbenzaldehyde 97%
• CAS NO: 63082-45-1
• Molecular Formula: C₈H₇FO
• Molecular Weight: 138.14
• EINECS: 1312995-182-4
• Product Categories: ALDEHYDE;Fluorobenzene;Carbonyl Compounds;Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Aldehydes;C8;Carbonyl Compounds;Benzaldehyde series
• Mol File: 63082-45-1.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 87 14mm
• Flash Point: 82 °C
• Appearance: /
• Density: 1.144 g/mL at 25 °C
• Vapor Pressure: 0.235mmHg at 25°C
• Refractive Index: 1.5260
• Storage Temp.: Room temperature.
• Sensitive: Air Sensitive
• CAS DataBase Reference: 4-Fluoro-2-methylbenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-2-methylbenzaldehyde(63082-45-1)
• EPA Substance Registry System: 4-Fluoro-2-methylbenzaldehyde(63082-45-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-41-37/38
• Safety Statements: 26-36-39
• WGK Germany: 3
• Hazardous Substances Data: 63082-45-1(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless to light yellow liquid

Uses

4-FLUORO-2-METHYLBENZALDEHYDE is a useful research chemical.

Purification Methods

The aldehyde has been purified by gas chromatography and should be kept under N2 as it readily oxidizes in air [Burgess et al. Aust J Chem 30 543 1977].

InChI:InChI=1/C8H7FO/c1-6-4-8(9)3-2-7(6)5-10/h2-5H,1H3

Upstream product

• 80141-91-9 (4-fluoro-2-methylphenyl)methanol 
• 202865-83-6 1-bromo-3-fluoro-5-methylbenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 95-52-3 2-Fluorotoluene 
• 201230-82-2 carbon monoxide 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 452-71-1 4-fluor-2-methylaniline 

Downstream Products

• 137586-78-8 3-(4-Fluoro-2-methylphenyl)-1-phenyl-2-propen-1-one 
• 946123-51-9 C₂₁H₁₈NF 
• 943441-91-6 (S)-1-benzhydryl-2-(4-fluoro-2-methylphenyl)-2,3-dihydropyridin-4(1H)-one 
• 137586-81-3 4-(4-Fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxaldehyde 
• 137587-00-9 4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine 
• 135426-34-5 4-(4-Fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol 
• 135426-57-2 3-(2,2-Dibromoethenyl)-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine 
• 137586-80-2 4-(4-Fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester 
• 137586-79-9 β-(4-Fluoro-2-methylphenyl)-α-(2-methyl-1-oxopropyl)-Δ-oxobenzenepentanoic acid, ethyl ester 
• 137587-01-0 (S)-4-({2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 137586-83-5 (S)-4-{[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester 
• 137593-79-4 (S)-4-({(E)-2-[4-(4-Fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 137593-78-3 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[4-(4-fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 137635-19-9 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-2-methyl-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 

Relevant articles and documents

Efficient and Highly Selective Solvent-Free Oxidation of Primary Alcohols to Aldehydes Using Bucky Nanodiamond

Selective oxidation of alcohols to aldehydes is widely applicable to the synthesis of various green chemicals. The poor chemoselectivity for complicated primary aldehydes over state-of-the-art metal-free or metal-based catalysts represents a major obstacle for industrial application. Bucky nanodiamond is a potential green catalyst that exhibits excellent chemoselectivity and cycling stability for the selective oxidation of primary alcohols in diverse structures (22 examples, including aromatic, substituted aromatic, unsaturated, heterocyclic, and linear chain alcohols) to their corresponding aldehydes. The results are comparable to reported transition-metal catalysts including conventional Pt/C and Ru/C catalysts for certain substrates under solvent-free conditions. The possible activation process of the oxidant and substrates by the surface oxygen groups and defect species are revealed with model catalysts, ex situ electrochemical measurements, and ex situ attenuated total reflectance. The zigzag edges of sp2 carbon planes are shown to play a key role in these reactions.

PYRROLOY2,3-c¨PYRIDINE COMPOUND, PROCESS FOR PRODUCING THE SAME, AND USE

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Roche has identified a 2,4,5-trisubstituted pyridine template for a new class of potent NK1 receptor antagonists. Previous strategies for construction of the pyridine core of these NK-1 receptor antagonists involved functionalization of a 2,5-disubstituted pyridine. We now report on construction of the pyridine core from commodity components. Shestopalov reported the synthesis of trans-4′-aryl-5′-cyano-1′,2′,3′, 4′-tetrahydro-6′-hydroxy-2′-oxo-1,3′-bipyridinium inner salts from 1-(2-amino-2-oxo-ethyl)pyridinium chloride, aromatic aldehydes, and ethyl cyanoacetate in the presence of a base. Reaction of these salts with phosphorus oxychloride affords 4-aryl-3-cyano-2,6-dichloropyridines. These are efficiently converted to nicotinamide precursors of the Roche NK-1 receptor antagonists by regioselective displacement of one chlorine by an amine, hydrogenolysis of the remaining chlorine, and nitrile hydrolysis.