6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

Base Information

• Chemical Name: 6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide
• CAS No.: 1152093-84-9
• Molecular Formula: C₂₃H₁₄ClN₅OS
• Molecular Weight: 443.916

Synonyms:6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

Chemical Property of 6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

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Technology Process of 6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

There total 1 articles about 6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

6-chloro-2-phenylpyrimidine-4-carbonyl chloride (1148122-15-9) + 2-(thiazolo[5,4-b]pyridin-2-yl)aniline (1152096-24-6) → 6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1152093-84-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In chloroform; at 20 ℃; for 0.5h;

Reference yield: 78.0%

6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1152093-84-9) + glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) → methyl 2-(2-phenyl-6-(2-(thiazolo[5,4-b]pyridin-2-yl)phenylcarbamoyl)pyrimidin-4-ylamino)acetate (1152093-93-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 0.333333h;

Reference yield: 57.0%

6-chloro-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1152093-84-9) + potassium ethoxide (917-58-8) → 6-ethoxy-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide (1152093-94-1)

Guidance literature:

In ethanol; dimethyl sulfoxide; at 120 ℃; for 0.166667h;

upstream raw materials:

6-chloro-2-phenylpyrimidine-4-carbonyl chloride

2-(thiazolo[5,4-b]pyridin-2-yl)aniline

Downstream raw materials:

6-(3-hydroxy-prop-1-ynyl)-2-phenyl-pyrimidine-4-carboxylic acid (2-thiazolo[5,4-b]pyridin-2-yl-phenyl)-amide

(S)-2-(2-phenyl-6-(2-(thiazolo[5,4-b]pyridin-2-yl)phenylcarbamoyl)pyrimidin-4-ylamino)propanoic acid

6-ethoxy-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

6-(3-aminopropoxy)-2-phenyl-N-(2-(thiazolo[5,4-b]pyridin-2-yl)phenyl)pyrimidine-4-carboxamide

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