5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride

Base Information

• Chemical Name: 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride
• CAS No.: 1469857-99-5
• Molecular Formula: C₂₄H₂₄N₆S*ClH
• Molecular Weight: 465.022
• Mol file: 1469857-99-5.mol

Synonyms:5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride

Chemical Property of 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride

There total 10 articles about 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

5-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine (1469858-70-5) → 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride (1469857-99-5)

Guidance literature:

With hydrogenchloride; In methanol; at 100 ℃; for 4h;

Reference yield: 49.0%

C31H39N5OSSi → 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride (1469857-99-5)

Guidance literature:

With hydrogenchloride; In methanol; water; at 100 ℃; for 4h;

Reference yield:

5,6-dihydro-<6H>-cyclopenta--thiophene-4-one (5650-51-1) → 5-{6-[4-(4-methylpiperazin-1-yl)phenyl]-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl}pyridin-2-ylamine hydrochloride (1469857-99-5)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydride / mineral oil; tetrahydrofuran / 8 h / 100 °C

2: hydrazine hydrate; acetic acid / ethanol / 4 h / 100 °C / Inert atmosphere

3: sodium hydride / mineral oil; tetrahydrofuran / 2.5 h / 0 - 80 °C

4: caesium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 8 h / 100 °C

5: N-Bromosuccinimide / 2 h

6: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; toluene / 8 h / 100 °C

7: hydrogenchloride / methanol; water / 4 h / 100 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; palladium diacetate; sodium hydride; sodium carbonate; caesium carbonate; hydrazine hydrate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; toluene; mineral oil;

upstream raw materials:

5-[6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalen-2-yl]pyridin-2-ylamine

6-(4-bromophenyl)-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

methyl 3-chlorobenzoate

6-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-trimethylsilanylethoxymethyl)-4,7-dihydro-1-thia-4,5-diazacyclopenta[a]pentalene

Refernces

• 1、 -. "HETEROCYCLIC PYRAZOLE COMPOUNDS, METHOD FOR PREPARING THE SAME AND USE THEREOF". Paragraph 0428-0429. . Retrieved 2013/10/22.