2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

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Chemical Name:2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione
CAS No.:770738-39-1
Molecular Formula:C₂₄H₂₆N₂O₅Si
Molecular Weight:450.566
Hs Code.:

Synonyms:2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

There total 4 articles about 2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1074-82-4
potassium phtalimide

: 770738-36-8
(R)-4-benzyl-3-{3-[(iodomethyl)dimethylsilyl]propanoyl}-1,3-oxazolidin-2-one

: 770738-39-1
2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: In acetonitrile; at 60 ℃; for 336h;
DOI:10.1002/hlca.200490152

Reference yield:

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 770738-39-1
2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pivaloyl chloride; NaH / tetrahydrofuran / 2 h

1.2: 84 percent / BuLi / tetrahydrofuran; hexane / 4 h / -78 - 23 °C

2.1: 97 percent / NaI / acetone / 48 h / 65 °C

3.1: 99 percent / acetonitrile / 336 h / 60 °C

With pivaloyl chloride; sodium hydride; sodium iodide; In tetrahydrofuran; acetone; acetonitrile; 2.1: Finkelstein reaction;
DOI:10.1002/hlca.200490152

Reference yield:

: 770738-34-6
3-[(chloromethyl)(dimethyl)silyl]propanoic acid

: 770738-39-1
2-[({3-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-oxopropyl}dimethylsilyl)methyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: pivaloyl chloride; NaH / tetrahydrofuran / 2 h

1.2: 84 percent / BuLi / tetrahydrofuran; hexane / 4 h / -78 - 23 °C

2.1: 97 percent / NaI / acetone / 48 h / 65 °C

3.1: 99 percent / acetonitrile / 336 h / 60 °C

With pivaloyl chloride; sodium hydride; sodium iodide; In tetrahydrofuran; acetone; acetonitrile; 2.1: Finkelstein reaction;
DOI:10.1002/hlca.200490152