(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Base Information

Chemical Name:(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione
CAS No.:1380696-16-1
Molecular Formula:C₂₀H₂₀N₂O₄
Molecular Weight:352.39
Hs Code.:

Synonyms:(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

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Chemical Property of (5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

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Technology Process of (5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

There total 16 articles about (5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57234-28-3
1-methoxy-3-(methoxymethoxy)benzene

: 1380696-16-1
(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 10 steps

1.1: n-butyllithium / tetrahydrofuran / 2 h / -78 - -70 °C

1.2: 2 h / 20 °C

2.1: hydrogenchloride / dichloromethane / 0.5 h

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

3.2: 2 h / 20 °C

4.1: tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) / toluene / 3 h / Reflux

5.1: boron tribromide / dichloromethane / 2 h / 20 °C / Cooling with ice

6.1: potassium carbonate / acetonitrile / 3 h / Reflux

7.1: ammonium chloride; zinc / water; tetrahydrofuran / 2 h / 40 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

9.1: hydrogenchloride / ethyl acetate / 0.5 h

10.1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With hydrogenchloride; n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; boron tribromide; sodium hydride; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; zinc; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;

Reference yield:

: 32315-10-9
bis(trichloromethyl) carbonate

: 1380697-56-2
N₁-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-D-alaninamide

: 1380696-16-1
(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1380696-16-1
(5R)-3-{4-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]phenyl}-5-methyl-2,4-imidazolidinedione

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 3 h / Reflux

2: ammonium chloride; zinc / water; tetrahydrofuran / 2 h / 40 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 100 °C / Microwave irradiation

4: hydrogenchloride / ethyl acetate / 0.5 h

5: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; zinc; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;