(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole
CAS No.:944836-38-8
Molecular Formula:C₁₄H₁₅BrF₃NO
Molecular Weight:350.178
Hs Code.:

Synonyms:(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Suppliers and Price of (S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

There total 4 articles about (S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: (S)-2-bromo-N-(1-hydroxy-3,3-dimethylbutan-2-yl)-5-(trifluoromethyl)benzamide

: 944836-38-8
(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 50 ℃; for 5h;
DOI:10.1016/j.tetlet.2010.08.039

Reference yield: 87.0%

: 1483-55-2
2-bromo-5-trifluoromethylbenzonitrile

: 112245-13-3
(S)-tert-leucinol

: 944836-38-8
(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Guidance literature:: With zinc(II) chloride; In diethyl ether; chlorobenzene; at 60 - 140 ℃; for 48h; Inert atmosphere;
DOI:10.1039/c2cc36452b

Reference yield:

: 944836-48-0
2-bromo-5-(trifluoromethyl)-benzoyl chloride

: 944836-38-8
(S)-2-(2-bromo-5-(trifluoromethyl)phenyl)-4-(tert-butyl)-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 2 steps

1: Na₂CO₃ / CH₂Cl₂; H₂O / 12 h / 20 °C

2: p-toluenesulfonyl chloride; triethylamine / CH₂Cl₂ / 22 h / 55 °C

With sodium carbonate; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; water;
DOI:10.1021/ol070884s