Technology Process of (S)-1-phenylbut-2-en-1-ol
There total 1 articles about (S)-1-phenylbut-2-en-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
phenylmagnesium bromide;
With
titanium(IV) isopropylate;
In
dichloromethane;
at -78 - 0 ℃;
Inert atmosphere;
crotonaldehyde;
With
(R)-3-(3,5-diphenylphenyl)-2,2'-dihydroxy-5,5',6,6',7,7',8,8'-octahydro-1,1'-binaphthyl;
In
diethyl ether; dichloromethane;
at 0 ℃;
for 3h;
Inert atmosphere;
With
hydrogenchloride; water;
In
diethyl ether; dichloromethane;
at 0 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1246/bcsj.20090232
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); N,N,N,N,-tetramethylethylenediamine;
In
1,4-dioxane; tert-Amyl alcohol;
at 110 ℃;
for 15h;
regioselective reaction;
Inert atmosphere;
DOI:10.1039/c3cc45772a
