4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester

Base Information

• Chemical Name: 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester
• CAS No.: 865544-89-4
• Molecular Formula: C₂₀H₁₆N₄O₃
• Molecular Weight: 360.372
• Mol file: 865544-89-4.mol

Synonyms:4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester

Chemical Property of 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester

There total 1 articles about 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 4-(2H-naphtho[1,2-d][1,2,3]triazol-2-yl)phenylcarboxylic acid (51887-37-7) → 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester (865544-89-4)

Guidance literature:

With hydrogenchloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 5 - 20 ℃;

DOI:10.1016/j.tet.2005.07.006

Reference yield: 87.0%

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester (865544-89-4) → 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid (865572-13-0)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2005.07.006

Reference yield:

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester (865544-89-4) → N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylamino acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / aq. NaOH / methanol / 4 h / 20 °C

2: HOBt; DCC / dimethylformamide / 5 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.07.006

upstream raw materials:

glycine ethyl ester hydrochloride

4-(2H-naphtho[1,2-d][1,2,3]triazol-2-yl)phenylcarboxylic acid

Downstream raw materials:

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid