4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid

Base Information

• Chemical Name: 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid
• CAS No.: 865572-13-0
• Molecular Formula: C₁₉H₁₄N₄O₃
• Molecular Weight: 346.345
• Mol file: 865572-13-0.mol

Synonyms:4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid

Chemical Property of 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid

There total 2 articles about 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester (865544-89-4) → 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid (865572-13-0)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2005.07.006

Reference yield:

4-(2H-naphtho[1,2-d][1,2,3]triazol-2-yl)phenylcarboxylic acid (51887-37-7) → 4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid (865572-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / HCl; DIPEA; HBTU / dimethylformamide / 5 - 20 °C

2: 87 percent / aq. NaOH / methanol / 4 h / 20 °C

With hydrogenchloride; sodium hydroxide; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.tet.2005.07.006

Reference yield: 7.0%

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid (865572-13-0) + 1-azido-1-deoxy-β-D-glucopyranoside tetraacetate (13992-25-1) → N-(2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl)-4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylamino acetamide

Guidance literature:

With tributylphosphine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.07.006

upstream raw materials:

4-naphtho[1,2-d][1,2,3]triazol-2-yl-benzoylaminoacetic acid methyl ester

4-(2H-naphtho[1,2-d][1,2,3]triazol-2-yl)phenylcarboxylic acid