(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Base Information

Chemical Name:(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester
CAS No.:847056-54-6
Molecular Formula:C₂₉H₃₁BrCl₃N₃O₇
Molecular Weight:719.844
Hs Code.:

(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Synonyms:(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Chemical Property of (S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

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Technology Process of (S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

There total 2 articles about (S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51301-86-1,57292-44-1,129101-26-4,68090-88-0
Boc-p-chloro-L-Phe-OH

: 847056-44-4
[(3aR,4R,6R,6aR)-6-(2-Bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-methanol

: 847056-54-6
(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm049450i

Reference yield:

: 142356-43-2
2-bromo-5,6-dichloro-1-β-D-ribofuranosylbenzimidazole

: 847056-54-6
(S)-2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid (3aR,4R,6R,6aR)-6-(2-bromo-5,6-dichloro-benzoimidazol-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / p-toluenesulfonic acid monohydrate / 1 h / 20 °C

2: N,N-dicyclohexylcarbodiimide; N,N-dimethylaminopyridine / dimethylformamide / 24 h / 20 °C

With dmap; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm049450i