C₂₃H₂₂FNO₂S

Base Information

• Chemical Name: C₂₃H₂₂FNO₂S
• CAS No.: 1393882-89-7
• Molecular Formula: C₂₃H₂₂FNO₂S
• Molecular Weight: 395.498
• Mol file: 1393882-89-7.mol

Synonyms:C₂₃H₂₂FNO₂S

Chemical Property of C₂₃H₂₂FNO₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₂FNO₂S

There total 4 articles about C₂₃H₂₂FNO₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

[2-(4-fluorophenyl)vinyl]boronic acid (214907-24-1) + N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine (543745-58-0) → C23H22FNO2S (1393882-89-7)

Guidance literature:

With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; In ethanol; water; at 100 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.tetlet.2012.06.089

Reference yield:

C20H24BrNO4S (1393956-43-8) → C23H22FNO2S (1393882-89-7)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate / ethanol; water / 0.5 h / 100 °C / Microwave irradiation

With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate; trifluoroacetic acid; In ethanol; dichloromethane; water; 2: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2012.06.089

Reference yield:

2-bromophenylethyl alcohol (1074-16-4) → C23H22FNO2S (1393882-89-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 °C

1.2: 16 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.1: potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; palladium diacetate / ethanol; water / 0.5 h / 100 °C / Microwave irradiation

With potassium phosphate; 1,1'-bis(di-tertbutylphosphino)ferrocene; di-isopropyl azodicarboxylate; palladium diacetate; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; 1.1: Mitsunobu reaction / 1.2: Mitsunobu reaction / 3.1: Suzuki-Miyaura coupling;

DOI:10.1016/j.tetlet.2012.06.089

upstream raw materials:

[2-(4-fluorophenyl)vinyl]boronic acid

N-[(4-methylphenyl)sulfonyl]-2-(2-bromophenyl)ethylamine

C₂₀H₂₄BrNO₄S

2-bromophenylethyl alcohol

Downstream raw materials:

C₂₃H₂₂FNO₂S