5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

Base Information

Chemical Name:5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile
CAS No.:943252-44-6
Molecular Formula:C₁₈H₁₆N₂OS
Molecular Weight:308.404
Hs Code.:

Synonyms:5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

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Chemical Property of 5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

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Technology Process of 5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

There total 5 articles about 5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 943252-40-2
3-amino-5-(4-methylphenyl)-2-thiophenecarbonitrile

: 504-02-9
1,3-cylohexanedione

: 943252-44-6
5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

Guidance literature:: With toluene-4-sulfonic acid; In toluene; for 4h; Heating;
DOI:10.1055/s-2007-965944

Reference yield:

: 943252-37-7
(Z)-3-chloro-3-(4-methylphenyl)-2-propenenitrile

: 943252-44-6
5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: Na₂S*9H₂O / dimethylformamide / 0.83 h / 50 °C

1.2: dimethylformamide / 1.5 h / 50 °C

1.3: 93 percent / NaOEt / dimethylformamide; ethanol / 0.5 h / 50 °C

2.1: 11 percent / p-toluenesulfonic acid*H₂O / toluene / 4 h / Heating

With sodium sulfide; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2007-965944

Reference yield:

: C₁₀H₁₀OClN

: 943252-44-6
5-(4-methylphenyl)-3-[(3-oxo-1-cyclohexen-1-yl)amino]-2-thiophenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: Ac₂O

2.1: Na₂S*9H₂O / dimethylformamide / 0.83 h / 50 °C

2.2: dimethylformamide / 1.5 h / 50 °C

2.3: 93 percent / NaOEt / dimethylformamide; ethanol / 0.5 h / 50 °C

3.1: 11 percent / p-toluenesulfonic acid*H₂O / toluene / 4 h / Heating

With sodium sulfide; acetic anhydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1055/s-2007-965944