methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

Base Information

Chemical Name:methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate
CAS No.:110914-36-8
Molecular Formula:C₁₆H₁₉NO₅
Molecular Weight:305.331
Hs Code.:

Synonyms:methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

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Chemical Property of methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

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Technology Process of methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

There total 4 articles about methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 116253-86-2
methyl 4-benzoylamino-2-oxo-3-butenoate

: 109-92-2,25104-37-4
ethyl vinyl ether

: 110914-36-8
methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

: 110914-28-8
methyl (2R,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

Guidance literature:: In toluene; at 135 ℃; for 12h; Product distribution; other enaminones, other vinyl ether or sulfide, other temperatures, other times, other solvent; exo/endo selectivity;

Reference yield:

: 110914-23-3
(E)-4-Benzoylamino-2-oxo-but-3-enoic acid methyl ester

: 109-92-2,25104-37-4
ethyl vinyl ether

: 110914-36-8
methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

: 110914-28-8
methyl (2R,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

Guidance literature:: With hydroquinone; In toluene; at 135 ℃; for 12h; Yield given. Yields of byproduct given;
DOI:10.1016/S0040-4039(00)85427-1

Reference yield:

: 110914-47-1
4-Ethoxy-2-oxobut-3-enoic acid methyl ester

: 110914-36-8
methyl (2S,4R)-(+/-)-4-benzoylamino-2-ethoxy-3,4-dihydro-2H-pyran-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NH₃

2: hydroquinone / toluene / 12 h / 135 °C

With ammonia; hydroquinone; In toluene;
DOI:10.1016/S0040-4039(00)85427-1