3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

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Chemical Name:3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester
CAS No.:1190422-80-0
Molecular Formula:C₄₀H₄₁FN₆O₅
Molecular Weight:704.801
Hs Code.:

3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

Synonyms:3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

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Chemical Property of 3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

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Technology Process of 3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

There total 10 articles about 3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3303-84-2
3-(tert-butyloxycarbonylamino)propionic acid

: 1187617-31-7
4-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]-2-(4-trans-hydroxycyclohexylamino)benzamide

: 1190422-80-0
3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

Guidance literature:: With dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 40h; Inert atmosphere;

Reference yield:

: 93583-49-4
methyl carbazole-4-carboxylate

: 1190422-80-0
3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

2: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

3: sodium hydroxide; methanol / 7 h / Reflux

4: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

5: acetic acid / 1 h / Reflux

6: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

7: dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

With methanol; dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; In petroleum jelly; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 52602-39-8
9H-carbazol-4-ol

: 1190422-80-0
3-tert-butoxycarbonylaminopropionic acid 4-trans-{2-carbamoyl-5-[4-(6-fluoro-1H-benzimidazol-2-yl)-9H-carbazol-9-yl]phenylamino}cyclohexyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: triethylamine / 1,3-bis-(diphenylphosphino)propane; palladium diacetate / N,N-dimethyl-formamide / 8 h / 50 °C / 1500.15 Torr / autoclave

3: sodium hydride / N,N-dimethyl-formamide; petroleum jelly / 20 °C / Inert atmosphere

4: sodium t-butanolate / palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene / toluene / 0.5 h / 115 °C / microwave irradiation

5: sodium hydroxide; methanol / 7 h / Reflux

6: N-ethyl-N,N-diisopropylamine; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 3.5 h / 20 °C

7: acetic acid / 1 h / Reflux

8: sodium hydroxide; water; dihydrogen peroxide / ethanol; dimethyl sulfoxide / 0.25 h / 20 °C

9: dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate / dichloromethane; N,N-dimethyl-formamide / 40 h / 20 °C / Inert atmosphere

With methanol; dmap; O-<[cyano(ethoxycarbonyl)methylene]amino>-1,1,3,3-tetramethyluronium tetrafluoroborate; water; dihydrogen peroxide; sodium hydride; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium t-butanolate; 1,1'-bis-(diphenylphosphino)ferrocene; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; In petroleum jelly; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;