barnidipine hydrochloride

Base Information

Chemical Name:barnidipine hydrochloride
CAS No.:104757-54-2
Molecular Formula:C₂₇H₂₉N₃O₆*ClH
Molecular Weight:528.005
Hs Code.:
Mol file:104757-54-2.mol

Synonyms:3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-pyrrolidinyl ester, monohydrochloride, [S-(R*,S*)]-

Suppliers and Price of barnidipine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of barnidipine hydrochloride

Chemical Property:

PSA：113.69000
LogP:5.41220

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of barnidipine hydrochloride

There total 5 articles about barnidipine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76093-34-0
(+)-(S)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)pyridine-3-carboxylic acid

: 104757-54-2,101979-04-8
(+)-(3'S,4S)-3-(1'-benzyl-3'-pyrrolidinyl) methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dimethylformamide; CH₂Cl₂ / 1 h

2: dimethylformamide; CH₂Cl₂ / 15 h

With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00162a013

Reference yield:

: 101469-91-4
(3S)-1-benzyl-3-hydroxypyrrolidine-2,5-dione

: 104757-54-2,101979-04-8
(+)-(3'S,4S)-3-(1'-benzyl-3'-pyrrolidinyl) methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride etherate, sodium borohydride / bis-(2-methoxy-ethyl) ether / 15 h / 100 °C

2: dimethylformamide; CH₂Cl₂ / 15 h

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00162a013

Reference yield:

: 100-46-9
benzylamine

: 104757-54-2,101979-04-8
(+)-(3'S,4S)-3-(1'-benzyl-3'-pyrrolidinyl) methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / ethanol / Heating

2: boron trifluoride etherate, sodium borohydride / bis-(2-methoxy-ethyl) ether / 15 h / 100 °C

3: dimethylformamide; CH₂Cl₂ / 15 h

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In ethanol; dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00162a013