methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

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Chemical Name:methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate
CAS No.:1354652-81-5
Molecular Formula:C₃₄H₃₅N₅O₄S
Molecular Weight:609.749
Hs Code.:

Synonyms:methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

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Chemical Property of methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

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Technology Process of methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

There total 8 articles about methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354652-78-0
methyl 3-(3-(chlorocarbonyl)benzylthio)propanoate

: 1354652-80-4
2-amino-N-(2-phenylpyrimidin-5-yl)-5-(piperidin-1-yl)benzamide

: 1354652-81-5
methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield:

: 6515-58-8
3-bromomethylbenzoic acid

: 1354652-81-5
methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 20 °C

2.1: potassium carbonate; water / methanol / 4 h / 60 °C

2.2: pH 3

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Inert atmosphere; Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere; Reflux

5.1: pyridine / tetrahydrofuran / 5 h / 20 °C

With pyridine; oxalyl dichloride; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 59808-52-5
5-amino-2-phenylpyrimidine

: 1354652-81-5
methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

2: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 2 h / 20 °C

3: pyridine / tetrahydrofuran / 5 h / 20 °C

With pyridine; dmap; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;