3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Base Information

Chemical Name:3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid
CAS No.:1354652-55-3
Molecular Formula:C₃₃H₃₃N₅O₄S
Molecular Weight:595.722
Hs Code.:

Synonyms:3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

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Chemical Property of 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

There total 9 articles about 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354652-81-5
methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate

: 1354652-55-3
3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: methyl 3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)-benzyl)thio)propanoate; With water; lithium hydroxide; at 20 ℃;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 6515-58-8
3-bromomethylbenzoic acid

: 1354652-55-3
3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 20 °C

2.1: potassium carbonate; water / methanol / 4 h / 60 °C

2.2: pH 3

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / Inert atmosphere; Reflux

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / Inert atmosphere; Reflux

5.1: pyridine / tetrahydrofuran / 5 h / 20 °C

6.1: water; lithium hydroxide / 20 °C

6.2: pH 4 - 5

With pyridine; oxalyl dichloride; water; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 59808-52-5
5-amino-2-phenylpyrimidine

: 1354652-55-3
3-((3-((2-((2-phenylpyrimidin-5-yl)carbamoyl)-4-(piperidin-1-yl)phenyl)carbamoyl)benzyl)thio)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 25 °C

2.1: hydrogen / palladium on activated charcoal / ethyl acetate; ethanol / 2 h / 20 °C

3.1: pyridine / tetrahydrofuran / 5 h / 20 °C

4.1: water; lithium hydroxide / 20 °C

4.2: pH 4 - 5

With pyridine; dmap; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate;