1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

Base Information

Chemical Name:1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol
CAS No.:637774-38-0
Molecular Formula:C₁₈H₂₈O₆
Molecular Weight:340.417
Hs Code.:

Synonyms:1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

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Technology Process of 1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

There total 4 articles about 1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 637774-37-9
3-O-tert-butyldimethylsilyl-1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

: 637774-38-0
1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1021/ol0358758

Reference yield:

: 109786-77-8
(S)-3-((4-methoxybenzyl)oxy)propane-1,2-diol

: 637774-38-0
1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / TEA; DMAP / CH₂Cl₂ / 18 h / 20 °C

2: 56 percent / NaH; tetrabutylammonium iodide / dimethylformamide / 18 h / 20 °C

3: 95 percent / tetra(n-butyl)ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With dmap; TEA; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0358758

Reference yield:

: 105-13-5
4-Methoxybenzyl alcohol

: 637774-38-0
1-O-(4-methoxybenzyl)-2-O-[2-(tetrahydro-2H-pyran-2-yloxy)ethyl]-sn-glycerol

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / diisobutylaluminum hydride / CH₂Cl₂; hexane / 70 h / 20 °C

2: 78 percent / TEA; DMAP / CH₂Cl₂ / 18 h / 20 °C

3: 56 percent / NaH; tetrabutylammonium iodide / dimethylformamide / 18 h / 20 °C

4: 95 percent / tetra(n-butyl)ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

With dmap; TEA; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol0358758