α,α-difluoro-4-phenylbenzeneacetic acid

Base Information

• Chemical Name: α,α-difluoro-4-phenylbenzeneacetic acid
• CAS No.: 73790-13-3
• Molecular Formula: C₁₄H₁₀F₂O₂
• Molecular Weight: 248.229
• Hs Code.: 2916399090
• Mol file: 73790-13-3.mol

Synonyms:α,α-difluoro-4-phenylbenzeneacetic acid

Chemical Property of α,α-difluoro-4-phenylbenzeneacetic acid

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Biphenylyl)-2,2-difluoroacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α,α-difluoro-4-phenylbenzeneacetic acid

There total 8 articles about α,α-difluoro-4-phenylbenzeneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

→ α,α-difluoro-4-phenylbenzeneacetic acid (73790-13-3)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield: 90.0%

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester (73789-98-7) → α,α-difluoro-4-phenylbenzeneacetic acid (73790-13-3)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201701248

Reference yield: 65.0%

2-([1,1'-biphenyl]-4-yldifluoromethyl)benzo[d]oxazole (1616729-49-7) → α,α-difluoro-4-phenylbenzeneacetic acid (73790-13-3)

Guidance literature:

2-([1,1'-biphenyl]-4-yldifluoromethyl)benzo[d]oxazole; With hydrogenchloride; water; zinc(II) chloride; In ethanol; at 80 ℃; for 12h;

With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

DOI:10.1039/c4cc03321c

upstream raw materials:

2-([1,1'-biphenyl]-4-yl)-2,2-difluoroacetic acid ethyl ester

ethyl (4-phenylphenyl)glyoxylate

4-iodo-biphenyl

2-([1,1'-biphenyl]-4-yldifluoromethyl)benzo[d]oxazole

Downstream raw materials:

[1,1′-biphenyl]-4-carbonyl fluoride

1-phenyl-4-(trifluoromethyl)benzene