(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Base Information

Chemical Name:(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide
CAS No.:1287286-73-0
Molecular Formula:C₂₄H₃₂N₂O₂
Molecular Weight:380.53
Hs Code.:

Synonyms:(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Suppliers and Price of (S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

There total 4 articles about (S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1287286-81-0
(R)-tert-butyl 2-((R)-(4-isobutoxyphenyl)((S)-2-phenylpropanamido)methyl)pyrrolidine-1-carboxylate

: 1287286-73-0
(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; for 6h;

Reference yield:

: 288086-98-6
[tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate]

: 1287286-73-0
(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0 - 65 °C

1.2: 0 °C

2.1: ammonium acetate / methanol / 0.5 h / 20 °C

2.2: 72 h / 60 °C

3.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

3.2: 4 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 3102.97 Torr

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 20 °C

5.2: 0.33 h / 40 °C / microwave

6.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

With hydrogenchloride; ammonium acetate; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 1287286-73-0
(S)-N-((R)-(4-isobutoxyphenyl)((R)-pyrrolidin-2-yl)methyl)-2-phenylpropanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C

1.2: 4 h / 20 °C

2.1: tetrahydrofuran / 0 - 65 °C

2.2: 0 °C

3.1: ammonium acetate / methanol / 0.5 h / 20 °C

3.2: 72 h / 60 °C

4.1: dicyclohexyl-carbodiimide; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / dichloromethane / 0.17 h / 20 °C

4.2: 4 h / 20 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 4 h / 3102.97 Torr

6.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / 20 °C

6.2: 0.33 h / 40 °C / microwave

7.1: hydrogenchloride / diethyl ether / 6 h / 20 °C

With hydrogenchloride; ammonium acetate; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; triphenylphosphine; diethylazodicarboxylate; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;