(R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

Base Information

• Chemical Name: (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine
• CAS No.: 288086-98-6
• Molecular Formula: C12H22N2O4
• Molecular Weight: 258.318
• Hs Code.: 2933998090
• Mol file: 288086-98-6.mol

Synonyms:1-(tert-butoxycarbonyl)-N-methoxy-N-methyl-D-prolinamide;(2R)-1-t-butoxycarbonyl-2-(N-methyl-N-methoxycarbamoyl)pyrrolidine;tert-butoxycarbonyl-D-proline-N-methoxy-N-methylamide;(2R)-2-{[methoxy(methyl)amino]carbonyl}pyrrolidin-1-ylcarboxylic acid tert-butyl ester;(R)-TERT-BUTYL 2-(N-METHOXY-N-METHYLCARBAMOYL)PYRROLIDINE-1-CARBOXYLATE;(R)-1-Boc-2-[methoxy(methyl)carbamoyl]pyrrolidine;(R)-2-(methoxy-methyl-carbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester;(R)-tert-butyl 2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester, (2R)-;1,1-dimethylethyl (R)-2-[(methoxymethylamino)carbonyl]pyrrolidine-1-carboxylate;

Chemical Property of (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

Chemical Property:

• PSA: 59.08000
• LogP: 1.34360

Purity/Quality:

99% ^*data from raw suppliers

(R)-tert-Butyl 2-(N-methoxy-N-methylcarbamoyl)pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

There total 8 articles about (R)-1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-D-proline (37784-17-1,59433-50-0) + N,0-dimethylhydroxylamine (1117-97-1) → [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] (288086-98-6)

Guidance literature:

N-(tert-butoxycarbonyl)-D-proline; With HATU; In dichloromethane; at 0 ℃; for 1h;

N,0-dimethylhydroxylamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 27 ℃; for 16h;

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-(tert-butoxycarbonyl)-D-proline (37784-17-1,59433-50-0) → [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] (288086-98-6)

Guidance literature:

With bis(isopropyl)ethylamine; HATU; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; at 20 ℃; for 2h;

Reference yield: 92.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + pivaloyl chloride (3282-30-2) + N-(tert-butoxycarbonyl)-D-proline (37784-17-1,59433-50-0) → [tert-butyl (R)-2-(methoxy(methyl)carbamoyl)pyrrolidine-1-carboxylate] (288086-98-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; triethylamine; In dichloromethane; cyclohexane; ethyl acetate;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

N-(tert-butoxycarbonyl)-D-proline

N,0-dimethylhydroxylamine

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl (2R)-2-acetylpyrrolidine-1-carboxylate

Refernces

• 1、 Mahajan, Deepak P,Godbole, Himanshu M,Singh, Girij P,Shenoy, Gautham G. "Synthesis of novel phase transfer catalysts derived from proline-mandelic acid/tartaric acid: their evaluation in enantioselective epoxidation and Darzen condensation". . . Retrieved 2019/02/27.
• 2、 -. "PROCESS FOR THE PREPARATION OF CHIRAL PYROLLIDINE-2-YL- METHANOL DERIVATIVES". Page/Page column 17-18. . Retrieved 2018/09/26.