5-(furan-2-yl)-3,4-dihydro-2H-pyrrole

Base Information

• Chemical Name: 5-(furan-2-yl)-3,4-dihydro-2H-pyrrole
• CAS No.: 104704-31-6
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.166
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID301289254
• Metabolomics Workbench ID: 48769
• Mol file: 104704-31-6.mol

Synonyms:104704-31-6;5-(furan-2-yl)-3,4-dihydro-2H-pyrrole;5-furan-2-yl-3,4-dihydro-2h-pyrrole;5-(2-Furanyl)-3,4-dihydro-2H-pyrrole;2-(2-furyl)-1-pyrroline;4-N-Maleimidophenyl?butanoic?acid;CHEBI:179148;RSWIYWDWUHQXIZ-UHFFFAOYSA-N;DTXSID301289254;MFCD09749693;AKOS005254770;5-(uran-2-yl)-3,4-dihydro-2H-pyrrole;2-(FURAN-2-YL)-4,5-DIHYDRO-3H-PYRROLE

Chemical Property of 5-(furan-2-yl)-3,4-dihydro-2H-pyrrole

Chemical Property:

• Vapor Pressure: 0.795mmHg at 25°C
• Refractive Index: 1.587
• Boiling Point: 189.2°Cat760mmHg
• Flash Point: 68.3°C
• PSA: 25.50000
• Density: 1.17g/cm³
• LogP: 1.29810
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 135.068413911
• Heavy Atom Count: 10
• Complexity: 153

Purity/Quality:

97% ^*data from raw suppliers

5-(Furan-2-yl)-3,4-dihydro-2H-pyrrole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(=NC1)C2=CC=CO2

Technology Process of 5-(furan-2-yl)-3,4-dihydro-2H-pyrrole

There total 2 articles about 5-(furan-2-yl)-3,4-dihydro-2H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

2-lithiofuran (2786-02-9) + 1-ethenyl-2-pyrrolidinone (88-12-0) → 5-[2]furyl-3,4-dihydro-2H-pyrrole (104704-31-6)

Guidance literature:

2-lithiofuran; 1-ethenyl-2-pyrrolidinone;

With hydrogenchloride;

With potassium hydroxide;

DOI:10.1016/j.tet.2004.10.006

Reference yield:

4-(furan-2-yl)-4-oxobutanenitrile (17960-37-1) → 5-[2]furyl-3,4-dihydro-2H-pyrrole (104704-31-6)

Guidance literature:

With nickel; Hydrogenation;

DOI:10.1039/jr9480000186

Reference yield: 60.0%

5-[2]furyl-3,4-dihydro-2H-pyrrole (104704-31-6) + benzyl bromide (100-39-0) → 1-benzyl-2-(furan-2-yl)pyrrolidine (1239144-57-0)

Guidance literature:

5-[2]furyl-3,4-dihydro-2H-pyrrole; With sodium tetrahydroborate; In ethanol; for 48h;

benzyl bromide; With triethylamine; In dichloromethane;

DOI:10.1021/jo101030b

upstream raw materials:

4-(furan-2-yl)-4-oxobutanenitrile

2-lithiofuran

1-ethenyl-2-pyrrolidinone

Downstream raw materials:

1-benzyl-2-(furan-2-yl)pyrrolidine

Refernces

• 1、 Shevchenko, Nikolay E.,R?schenthaler, Gerd-Volker,Mitiaev, Alexander S.,Lork, Enno,Nenajdenko, Valentine G.. "Diastereoselective synthesis of cyclic 1,3-aminoalcohols bearing CF3(CCl3)-groups". scheme or table. p. 637 - 644. Retrieved 2009/04/03.
• 2、 KNOTT. "beta-Cycloylpropionitriles; reduction to 2-cyclyl-delta2-pyrrolines and". . p. 186 - 188. Retrieved 2007/10/04.