N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide
CAS No.:1551453-75-8
Molecular Formula:C₂₃H₁₄ClF₂N₃O₃S
Molecular Weight:485.898
Hs Code.:

Synonyms:N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

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Chemical Property of N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

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Technology Process of N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

There total 7 articles about N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.7%

: 1093819-56-7
N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1551454-34-2
6-bromo-4-(3-hydroxyprop-1-yn-1-yl)quinoline

: 1551453-75-8
N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; In 1,4-dioxane; water; at 90 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 145369-94-4
6-bromoquinolin-4-ol

: 1551453-75-8
N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / toluene / 4 h / 115 °C

2: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

3: sodium iodide / 96 h / Reflux

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; sodium iodide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; N,N-dimethyl-formamide; toluene; 5: |Suzuki Coupling;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1551453-75-8
N-(2-chloro-5-(4-(3-hydroxyprop-1-yn-1-yl)quinolin-6-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: cycl-isopropylidene malonate / ethanol / 4 h / 85 °C

2: 1,2-dichloro-benzene / 6.5 h / 0 - 188 °C

3: trichlorophosphate / toluene / 4 h / 115 °C

4: hydrogenchloride / tetrahydrofuran; diethyl ether / 0.5 h / 20 °C

5: sodium iodide / 96 h / Reflux

6: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / water; 1,4-dioxane / 1.5 h / 90 °C / Inert atmosphere

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; cycl-isopropylidene malonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; triethylamine; sodium iodide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; 1,2-dichloro-benzene; toluene; 7: |Suzuki Coupling;