1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

Base Information

• Chemical Name: 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone
• CAS No.: 75896-41-2
• Molecular Formula: C₁₂H₁₁NO₃S
• Molecular Weight: 249.29
• Mol file: 75896-41-2.mol

Synonyms:1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

Chemical Property of 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

There total 2 articles about 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

recorcinol (108-46-3) + (4-methylthiazol-2-yl)acetonitrile (19785-39-8) → 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone (75896-41-2)

Guidance literature:

recorcinol; (4-methylthiazol-2-yl)acetonitrile; With boron trifluoride diethyl etherate; In diethyl ether; at 25 - 27 ℃; for 0.166667h;

With hydrogenchloride; In diethyl ether; at 30 - 40 ℃; for 6h;

DOI:10.1039/c3md00338h

Reference yield:

4-methyl-2-thiazolylacetonitrile hydrobromide + recorcinol (108-46-3) → 1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone (75896-41-2)

Guidance literature:

With hydrogenchloride; boron trifluoride diethyl etherate; water; Yield given. Multistep reaction; 2.) 1 h;

DOI:10.1007/BF01177015

Reference yield: 44.0%

1-(2,4-dihydroxyphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone (75896-41-2) + 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide (572-09-8) → Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-{3-hydroxy-4-[2-(4-methyl-thiazol-2-yl)-acetyl]-phenoxy}-tetrahydro-pyran-3-yl ester

Guidance literature:

With potassium hydroxide; In acetone; for 4h; Ambient temperature;

DOI:10.1007/BF00630111

upstream raw materials:

recorcinol

(4-methylthiazol-2-yl)acetonitrile