5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

Base Information

Chemical Name:5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol
CAS No.:1185908-03-5
Molecular Formula:C₁₅H₁₁F₂N₇O
Molecular Weight:343.295
Hs Code.:

Synonyms:5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

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Chemical Property of 5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

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Technology Process of 5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

There total 4 articles about 5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185908-02-4
5-[2-(2,3-difluoro-phenyl)-ethyl]-7-hydroxy-pyrazolo[1,5-a]pyrimidine-2-carbonitrile

: 1185908-03-5
5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 48h;

Reference yield:

: 1185908-14-8
2-benzyloxymethyl-5-[2-(2,3-difluoro-phenyl)-ethyl]-pyrazolo[1,5-a]pyrimidin-7-ol

: 1185908-03-5
5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen; acetic acid / 10 wt% Pd(OH)2 on carbon / methanol / 25 °C / 750.08 Torr

2: manganese(IV) oxide / chloroform; N,N-dimethyl-formamide / 7 h / 60 °C

3: hydroxylamine hydrochloride; sodium acetate / water / 3 h / Reflux

4: sodium acetate; acetic anhydride / 18 h / 100 °C

5: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 48 h / 120 °C

With manganese(IV) oxide; sodium azide; hydroxylamine hydrochloride; hydrogen; sodium acetate; acetic anhydride; ammonium chloride; acetic acid; 10 wt% Pd(OH)2 on carbon; In methanol; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 1185907-99-6
5-[2-(2,3-difluoro-phenyl)-ethyl]-7-hydroxy-pyrazolo[1,5-a]pyrimidine-2-carbaldehyde oxime

: 1185908-03-5
5-[2-(2,3-difluoro-phenyl)-ethyl]-2-(1H-tetrazol-5-yl)-pyrazolo[1,5-a]pyrimidin-7-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; acetic anhydride / 18 h / 100 °C

2: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 48 h / 120 °C

With sodium azide; sodium acetate; acetic anhydride; ammonium chloride; In N,N-dimethyl-formamide;